LETTER TO THE EDITOR Caution needed in fluoride and osteosarcoma study

with results from an analysis of a subset of participants in our ongoing study of fluoride and osteosarcoma. The paper, ‘‘Age-specific fluoride exposure in drinking water and osteosarcoma’’, presents a partial view of this ongoing study. We would like to advise the readers to be especially cautious when interpreting the findings of this paper for several reasons. The authors themselves have already raised a flag of caution in their final paragraph with the note that they are aware of additional findings from other inci-dent cases that appear not to replicate the findings from the cases presented in their paper. The Harvard School of Dental Medicine study of fluo-ride and osteosarcoma has been a 15-year collaboration among NIEHS, NCI, NIDCR, and Harvard. Two sets of cases have been collected each with their own contro