Nigeria. WHO Regional Reference Polio Laboratory, WHO Collaborative Centre for Arbovirus Reference and Research, WHO National Reference Centre for Influenza

Abstract: This study reports on antibiotic sensitivity and resistance patterns of uropathogens to nitrofurantoin and nalidixic acid in Ibadan, Nigeria. The susceptibility and resistance patterns of 38 bacterial pathogens were determined using standard procedures. Based on the standard zones of inhibition ranging from 17mm-37mm in diameter exhibited by the pathogens, most of the isolates were highly sensitive to Nitrofurantoin and Nalidixic acid with lethal effects. The antibiogram studies also showed that E. coli in most clinical samples was highly sensitive to Nitrofurantoin, which were found to be 100 % effective in-vitro against the E. coli, followed by and Klebsiella sp. (85.7%) and S. aureus (72.7%) study while sensitivity to Nalidixic acid were higher for E. coli (75%), followed by and Klebsiella sp. (71.4%) and Pseudomonas aeruginosa (50%). The resistance pattern showed that S. aureus was highly resistance to Nalidixic acid (63.6%), followed by P. aeruginosa (50%)