I n a c t i vation of this gene leads to the inability of a cell with DNA damage to induce cell cycle arrest to allow time for DNA repair or the induction of apoptosis.2,3 Wild-type p53 may be inactivated by complex form ation with mutant p53, viral or aberr a n t host-binding proteins.4, 5 The mutated p53 gene product is more stable than the wild-type and can be demonstrated immunohistochemically in tissue sections.3 According to most studies p53 is not detected in normal oral mucosa6-10 but it can be demonstrated with immunohistochemical techniques in oral mucosal squamous cell carcinomas (OMSCC) and potentially malignant oral mucosal lesions.11 Most reports have shown that there is an increase in the proportion of cases that show p53 abn...
Aim: To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma to det...
Contains fulltext : 185702.pdf (publisher's version ) (Closed access)Oral squamous...
The role of p53 mutation in oral cancer cases has not been studied in Malaysia. This study was desig...
Recent studies have shown the accumulation of high levels of p53 protein to be associated with malig...
Introduction: Expression of p53 gene is one of the common findings in premalignancies and malignanci...
Squamous cell carcinoma (SCC) is the commonest cancer in the mouth. Multiple risk factors, such as s...
Background and purpose: In our previous study, positive p53 staining was observed in 47 of 81 (58%) ...
The expression of p53 in oral mucosal disorders is strongly associated with malignant disease. Smear...
Oncoprotein p53 actively participates in oral carcinogenesis, in its initiation and/or promotion of...
Oral precancerous lesions have been considered as a target tissue for the early detection and chemop...
With the ultimate goal of characterizing the molecular pathogenesis of oral cancer, the most predomi...
Aim: To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma to det...
Background: Squamous cell carcinoma is a malignancy of oral cavity mostly occurred and can also meta...
P53 is a nuclear phosphoprotein encoded by the tumor suppressor gene p53. This P53 protein plays an ...
Recent reports of p53 positivity in the normal mucosa of some head and neck cancer patients have bee...
Aim: To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma to det...
Contains fulltext : 185702.pdf (publisher's version ) (Closed access)Oral squamous...
The role of p53 mutation in oral cancer cases has not been studied in Malaysia. This study was desig...
Recent studies have shown the accumulation of high levels of p53 protein to be associated with malig...
Introduction: Expression of p53 gene is one of the common findings in premalignancies and malignanci...
Squamous cell carcinoma (SCC) is the commonest cancer in the mouth. Multiple risk factors, such as s...
Background and purpose: In our previous study, positive p53 staining was observed in 47 of 81 (58%) ...
The expression of p53 in oral mucosal disorders is strongly associated with malignant disease. Smear...
Oncoprotein p53 actively participates in oral carcinogenesis, in its initiation and/or promotion of...
Oral precancerous lesions have been considered as a target tissue for the early detection and chemop...
With the ultimate goal of characterizing the molecular pathogenesis of oral cancer, the most predomi...
Aim: To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma to det...
Background: Squamous cell carcinoma is a malignancy of oral cavity mostly occurred and can also meta...
P53 is a nuclear phosphoprotein encoded by the tumor suppressor gene p53. This P53 protein plays an ...
Recent reports of p53 positivity in the normal mucosa of some head and neck cancer patients have bee...
Aim: To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma to det...
Contains fulltext : 185702.pdf (publisher's version ) (Closed access)Oral squamous...
The role of p53 mutation in oral cancer cases has not been studied in Malaysia. This study was desig...