ORIGINAL CONTRIBUTION A Calcium Antagonist vs a Non–Calcium Antagonist Hypertension Treatment Strategy for Patients With Coronary Artery Disease The International Verapamil-Trandolapril Study (INVEST): A Randomized Controlled Trial

for the INVEST Investigators THE PREVALENCE OF CORONARYartery disease (CAD) is increas-ing, as are major CAD risk fac-tors (hypertension, aging, dia-betes, obesity, and inactivity).1 Blood pressure is important in the progres-sion of CAD, yet no large trials have evaluated blood pressure manage-ment in only patients with CAD. Thus, bloodpressuremanagement inCADpa-tients2must be guidedbydata from rela-tively small subsets of high-risk pa-tients from other trials.3-6 Current trends inhypertensionman-agement emphasize multidrug regi-mens rather than monotherapy. Com-binationsof antihypertensivedrugswit