• BRIEF REPORT • Influence of BOL on hyaluronic acid, laminin and hyperplasia in hepatofibrotic rats

AIM: To study the anti-hepatofibrosis mechanism of Bie Jia Jian oral liquid (BOL). METHODS: The model was induced by subcutaneous injection of CCl4. BOL was administered and the change of serum hyaluronic acid (HA) and lamin in (LN) was observed and the degeneration of liver cells and the degree of fibre hyperplasia analyzed. Changes of ultra micro-structure in liver cells were observed in some samples. RESULTS: HA was reduced in both the groups with low and high dosage of BOL, which showed a remarkable difference as compared with that of the model group ( low dosage group: 376.15 µg/L±35.48 µg/L vs 806.07 µg/L±98.49 µg/L, P<0.05; high dosage group: 340.14 µg/L±30.18 µg/L vs 806.07 µg/L±98.49 µg/L, P<0.05). The LN content of low and high dosage group of BOL was lower than that of model group (low dosage group: 71.99 µg/L±8.15 µg/L vs 133.94 µg/L±14.45 µg/L, P<0.01; high dosage group: 71.68 µg/L±11.6