WHAT AFTER CIPROFLOXACIN AND CEFTRIAXONE IN TREATMENT OF SALMONELLA TYPHI

Objective: To determine resistance pattern of Salmonella typhi in blood cultures. Design: Laboratory-based observational study. Material and Methods: Blood samples processed during the period of one and half year in the laboratory of Fatima Memorial Hospital for culture sensitivity were followed. Sensitivity of Salmonella typhi isolates was checked to 20 different antibiotics. Report of culture and sensitivity pattern was recorded. Results: Amongst the 86 isolate 45 were found to be resistant to 2 or more first line anti-salmonella drugs. Eighteen multi-drug resistant Salmonella typhi (MDRST), isolates were detected. Four of the MDRST isolates were resistant to each of ciprofloxacin and ceftriaxone, and two were resistant to both of these drugs. Resistance was 19.2 % to ciprofloxacin and 17.5 % to ceftriaxone. Sensitivity to meropenem was 100 % and to imipenem 98.6%. Conclusion: Pattern of S. typhi resistance is changing rapidly. MDRST and strains resistant to ciprofloxacin and ceftriaxone are a major threat in developing world. Proper steps must be taken to avoid emergence of Salmonella typhi strains resistant to most of the pertinent antibiotics