Permanent and functional male-to-female sex reversal in d-rR strain medaka (Oryzias latipes) following egg microinjection of o,p´-DDT. Environ Health Perspect 108:219–224

Teleost sexual differentiation is sensitive and responsive to manipulation by exogenous estrogen and androgen steroid hormones (1–3). A variety of environmental chemicals demonstrate intrinsic activity at teleost steroid receptors (4–7) and steroidogenic pathways (8–9) and therefore could poten-tially alter normal sexual differentiation and development in feral and laboratory fish pop-ulations. Although the induction of the egg yolk lipoprotein vitellogenin in male fish has received attention as a sensitive biomarker for estrogen exposure (10–12), relatively few studies have focused on long-term permanent adverse reproductive effects of xenobioti