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Mlytic T-lymphocytes (CTL) upon antigen stimulation in the context of infection and inflammation. During this process, the differenti-ating cells induce the expression of effector proteins such as the T cell differentiation has been difficult to discern in vivo because results from infection of IL-2-deficient mice have differed. This variabilitymay reflect autoimmunity secondary to defective regu-cytokine IFNg, the pore-forming protein perforin, and a family of serine esterases known collectively as granzymes (Cruz-Guilloty et al., 2009; Harty et al., 2000). Perforin and granzymes are latory T cell development in IL-2-deficient mice (Bachmann an