Association between the neuregulin 1 gene and schizophrenia: a systematic review. Schizophr Bull

Chromosome 8p22–p11 has been identified as a locus for schizophrenia in several genome-wide scans, which has been confirmed by meta-analysis of published linkage data. It appears to be 1 of the most robust linkage findings in psychosis. Several attempts have been made to identify the underlying genetic variation that gives rise to this linkage peak, including systematic fine mapping using extended Icelandic pedigrees that have identified an associated hap-lotype (HAPICE) in the gene neuregulin 1, also known as heuregulin, glial growth factor, NDF43, and ARIA. Neure-gulin 1 (NRG1) is a plausible susceptibility gene because of its involvement in neurodevelopment, regulation of gluta-mate and other neurotransmitter receptor expression, and synaptic plasticity. Encouragingly, this finding was quickly and directly replicated in a Scottish case-control sample b