Fibrodynamics-elucidation of the mechanisms and sites of liver fibrogenesis

Subject headings liver cirrhosis/pathology; liver cirrhosis/etiology; liver cirrhosis/ physiopathology; fibrodynamics; hepatic stellate cells ORIGINAL ARTICLE Dynamic changes of type I, III and IV collagen synthesis and distribution of col lagen-producing cells in carbon tetrachloride- induced rat liver fibrosis. MAJOR POINTS OF THE COMMENTED ARTICLE In their article that appears in this issue, Du and colleagues used a combination of immunohistochemistry and in situ hybridization to demonstrate increased levels of collagen types I, III and IV in CCl4/choline deficient rat model of hepatic fibrosis. Over the course of 20 weeks o