ANGIOTENSIN-1 CONVERTING ENZYME I/D

Abstract. Discrepancies in angiotensin-1 converting enzyme (ACE) allele genetic susceptibility with disease etiology have been attributed to ethnic differences. We investigated ACE gene polymorphism of the multiethnic Malaysian population by utilizing nested polymerase chain reaction. Allelic frequency of 0.65 and 0.35 for I and D allele, respectively in the pooled popu-lation was comparable with other Asian populations. A significant association was found be-tween the Malaysian ethnic groups and ACE I/D genotype. The II genotype was found at higher frequency among the Malays but a greater frequency of DD genotype among Indians. gested that there is no association of disease etiology with ACE I/D gene polymorphism (Schimdt et al, 1995, Agerholm-Larsen et al, 1997; Clark et al, 2000; Moleda et al, 2006; Nacmias et al, 2007)