Effect of Garlic (Allium sativum) on Some Heavy Metal (Copper and Zinc) Induced Alteration in Serum Lipid Profile of Oreochromis niloticus

Abstract: This study was conducted to investigate the effect of treatment with garlic oil (Allium sativum) on some heavy metal (copper and zinc) toxicity in Oreochromis niloticus. groups of Nile tilapia fed on six different diets, the concentration of CuSO4 was 300 mg/kg diet and ZnSO4 400 mg/kg diet. Garlic oil was added with concentration of 250 mg/kg diet, the experiment was extended for three months. Bioacuumulation of copper and zinc were obvious in treated fish as monitored by the significant (P<0.01) increase in serum and liver tissues concentrations, but they were decreased significantly after treatment with Allium sativum. Lipid profile like, triglyceride (TG), cholesterol, very low density lipoprotein (VLDL), low density lipoprotein (LDL) showed significant increase. But high density lipoprotein (HDL) level significantly decrease after treatment with heavy metal. Simultaneous garlic administration with copper sulfate and zinc sulfate showed improvement in serum cholesterol, LDL, HDL, VLDL, TG, Ceruloplasmin, glutathione peroxidase and Malonyldialdehyde. The results indicate that garlic (Allium sativum) has some beneficial effect in preventing heavy metal (copper and zinc) induced alterationi of lipid profile. Key words: Garlic (Allium sativum) % Copper sulfate % Zinc sulfate % Lipid peroxidation % Serum lipid profile INTRODUCTION Garlic administration (Allium sativum) has some The toxicity of essential elements such as Cu and Zn chromium VI) induced alteration in lipid profile [7]. Th