Add to ORKGmouse schwannomas, grades II and III. At the molecular level, analysis of the tumors revealed almost complete loss of both NF proteins, despite the fact that transcript levels were increased, implying posttranscriptional regu-lation. Although Erk and Akt signaling are typically en tiva-tion of either of these pathways in TEC3KO tumors. hoA are all known to be involved with NF signaling. In TEC ases in total protein, but only Rac1 showed significant ac n ki-nase A activation causes tumorigenesis through path d in NF tumorigenesis