Add to ORKGProteins exploit the conformational variability of loop regions to carry out diverse biological tasks including molecular recognition, signal transduction, and active site gating. New algorithms to engineer these functions by combining loop building and sequence design therefore have enormous practical applications, but require high-resolution loop reconstruction: the modeling of protein loop conformations given amino acid sequences. Despite significant progress in loop prediction1-3, more accurate methods to sample and evaluate the conformational space accessible to loops are still a major bottleneck for high-resolution protein modeling. Loop reconstruction in protein design may be simplified conceptually by restricting changes to the func...
Methods to predict the structure of a protein often rely on the knowledge of macro sub-structures an...
Background: Protein loops are flexible structures that are intimately tied to function, but understa...
Cette thèse introduit le premier modèle paramétrique global d'une boucle de protéine, qui soit passi...
The efficient filtering of unfeasible conformations would considerably benefit the exploration of th...
International audienceThe efficient filtering of unfeasible conformations would considerably benefit...
Motivated by recently developed computational techniques for studying protein flexibility, and their...
This thesis introduces the first global parametric model of protein loops amenable to effective samp...
Motivated by recently developed computational techniques for studying protein flexibility, and their...
International audienceAbstract Flexible loops are paramount to protein functions, with action modes ...
Methods to predict the structure of a protein often rely on the knowledge of macro-sub-structures an...
The ability to efficiently sample structurally diverse protein conformations allows one to gain a hi...
International audienceMotivation: Loop portions in proteins are involved in many molecular interacti...
Proteins perform most of biological functions. The ultimate approach to understand protein functions...
Exploration In this paper we propose a robotics-inspired method to enhance sampling of native-like c...
Consistently predicting biopolymer structure at atomic resolution from sequence alone remains a diff...
Methods to predict the structure of a protein often rely on the knowledge of macro sub-structures an...
Background: Protein loops are flexible structures that are intimately tied to function, but understa...
Cette thèse introduit le premier modèle paramétrique global d'une boucle de protéine, qui soit passi...
The efficient filtering of unfeasible conformations would considerably benefit the exploration of th...
International audienceThe efficient filtering of unfeasible conformations would considerably benefit...
Motivated by recently developed computational techniques for studying protein flexibility, and their...
This thesis introduces the first global parametric model of protein loops amenable to effective samp...
Motivated by recently developed computational techniques for studying protein flexibility, and their...
International audienceAbstract Flexible loops are paramount to protein functions, with action modes ...
Methods to predict the structure of a protein often rely on the knowledge of macro-sub-structures an...
The ability to efficiently sample structurally diverse protein conformations allows one to gain a hi...
International audienceMotivation: Loop portions in proteins are involved in many molecular interacti...
Proteins perform most of biological functions. The ultimate approach to understand protein functions...
Exploration In this paper we propose a robotics-inspired method to enhance sampling of native-like c...
Consistently predicting biopolymer structure at atomic resolution from sequence alone remains a diff...
Methods to predict the structure of a protein often rely on the knowledge of macro sub-structures an...
Background: Protein loops are flexible structures that are intimately tied to function, but understa...
Cette thèse introduit le premier modèle paramétrique global d'une boucle de protéine, qui soit passi...