COMMENTARY Thrombophilia and pregnancy loss in first intended pregnancy

pregnancy; the matched case–control ‘NOHA first ’ study. This issue, pp 2178–84. Recurrent pregnancy loss is a common health problem affecting 1–5 % of women at the reproductive age and bears significant emotional, social and economical impact [1]. A number of case–control and cohort studies have suggested an association between inherited thrombophilia and recurrent pregnancy loss while others refuted this occurrence [2–6]. Several recently reported meta-analysis support an association between maternal factor V Leiden (FV Leiden) and factor II G20210A genotypes and pregnancy loss [7–9]. These findings have lead to the introduction of thrombo-philia workup in women at risk, particularly in those with recurrent or late pregnancy loss. Documentation of thrombo-philic risk factors in womenwith pregnancy complications may have significant therapeutic implications as a number of clinica