Imaging Degeneration of the Substantia Nigra in Parkinson Disease with Inversion-Recovery MR Imaging

BACKGROUND AND PURPOSE: Visualizing with MR imaging and obtaining quantitative indexes of degeneration of the substantia nigra in Parkinson disease have been long-sought goals. We investi-gated the potential role of area and T1 contrast measurements in differentiating patients from controls and their age-related changes. METHODS: Eight patients with Parkinson disease, 8 age-matched controls, and 8 young controls were imaged. We obtained the pixel-wise difference between 2 sets of inversion-recovery images, acquired parallel to the bicommissural plane, with different inversion times. Pixel-intensity ratios between lateral and medial nigral regions, and nigral area and substantia-nigra/midbrain area ratios were computed. RESULTS: Compared with that of controls, loss of substantia nigra was evident in patients, its borders taking a smoother and more irregular appearance. Patients were characterized by a lateral-to-medial gradient, due to reduced hypointensity of the lateral portion of the substantia nigra and relative sparing of its medial portion. The visible nigral area was significantly smaller in patients compared with matched controls (P .04). The substantia nigra/midbrain area ratio enabled considerably better separation (P .0001). The lateral/medial pixel-intensity ratio was significantly higher in patients compared with matched controls (P .01) and in young controls compared with age-matched control