Capillary Electrophoresis-a New Clinical Tool

The potential clinical diagnostic utility of capillary electro-phoresis in an open-tubular column is established. Sep-aration patterns for serum proteins by conventional aga-rosegelelectrophoresis can be faithfully reproduced by a capillary electrophoresis procedure that provides the complete run data in 8 mm. Hemoglobin variants can be separated within 10 mm. The capillary electrophoresis separations are performed reliably and reproducibly in an untreated 75 Mm (i.d.) x 25 cm fused-silica column. Diluted serum or hemoglobin samples can be loaded on an automated instrument with on-line injection, detection, and quantification, providing a truly “walkaway ” electro-phoresis system. AddItIonalKeyphrases:proteins hemoglobin urine cerebrospinal fluid agarose gel electrophoresis compare