Editorial: Clustering of Schizophrenia With Other Comorbidities—What Can We Learn?

Despite great efforts to the contrary, the molecular basis underlying schizophrenia and many other psychiatric disorders remains elusive. Examination of the nonpsychi-atric manifestations that sometimes accompany schizo-phrenia provides opportunities to more fully explore the scope of biochemical and metabolic abnormalities characterizing the disease spectrum. This issue of the Journal features a series of articles that focus on the systemic manifestations of schizophrenia. A more complete understanding of disease spectrum can provide important insights into disease etiology. For example, pathologic analyses of atherosclerotic vas-cular tissue revealed the presence of immune infiltrates, thereby helping to revamp our view of coronary artery disease as an inflammatory disease.1 In the psychiatri