Concurrent Proton Beam Radiotherapy and Systemic Chemotherapy for the Metastatic Liver Tumor of Gastric Carcinoma: a Case Report

We report a case of a woman with a metastatic liver tumor from gastric carcinoma, who has been successfully treatedwithconcurrentprotonbeamtherapyandsystemicchemotherapy.A76-year-old woman underwent distal gastrectomy with regional lymph node dissection for advanced gastric carcinoma on January 17, 2002. She received five courses of sequential chemotherapy with methotrexate–5-fluorouracil after the surgical resection. A metastatic liver tumor was detected in the caudate lobe of the liver by computed tomography at 6 months after the surgical resection. We employed concurrent proton beam therapy and systemic chemotherapy which consisted of 5-fluorouracil (250 mg/body per day, as a 24-h intravenous injection for 4 weeks) and low dose cisplatin (10 mg/body on days 1–5 every week for 4 weeks). Proton beam therapy targeting themetastatic liver tumorwasperformed inadaily fractionof3Gy,5daysperweek,witha total dose of 66 Gy over 30 days. The tumor disappeared 3 months after the treatment and no recurrence has been observed for 2 years after termination of the treatment. Throughout the entire course of treatment, the patient received injections of granulocyte stimulating factor subcutaneously for grade 3 leukopenia. She never complained of abdominal symptoms, such as epigastralgia, nauseaor diarrhea. Liver failure related to proton irradiation hasnot beenobserved. This concurrent proton beam radiotherapy with systemic chemotherapy could be an effective treatment modality for metastatic liver tumor from gastric carcinoma. Key words: chemoradiotherapy – 5-fluorouracil – gastric carcinoma – metastatic liver tumor – proto