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Garcia-Solis et al. 2005). It has been suggested that in thyroid gland the apoptotic iodide (IK) effect is rats (Funahashi et al. 1996, Garcia-Solis et al. 2005). ined by the oxidizes IK and covalently binds it to the milk protein casein, is 2007). Recently, we also showed that methylnitro-Endocrine-Related Cancer (2008) 15 1003–10112004) and exerts a potent antineoplasic effect onmediated by the derivatives of arachidonic acid (AA) or eicosapentaenoic acid such as 6-iodolactone (6-IL) or a-iodohexadecanal respectively (Dugrillon et al. 1994, Pisarev et al. 1994, Langer et al. 2003). The formation of these iodolipids requires, in addition to iodide uptake by specific transporters, its oxidation by thyroperoxidase (Shah et al. 1986, Dohan et al. 2003)