from Zucker Diabetic Fatty rats (ZDF/GMI-fa/fa) Effects of chronic treatment with glibenclamide and/or metformin on the resistance to ischaemia of isolated hearts Published by:

The study was carried out to determine whethermetformin (M) had any deleterious effect on thetolerance to ischaemia of the isolated diabetic rat when administered chronically in combination with glibenclamide (G). The male Zucker Diabetic Fatty (ZDF) rat served as a model of type 2 diabetes that resembles the human syndrome. Three groups of rats were treated for one month with M (100 mg/kg) or G (2 mg/kg) or G + M in their daily food. One group was untreated (C). Aortically perfused hearts were subjected to a 25-minute global low-flow ischaemia and a 30-minute reperfusion. Heart rate (HR), left ventricular developed pressure (LVDP), rate pressure product (RPP) and coronary flow (CF) were monitored. When compared to C hearts, the hearts from G + M rats showed improvements in HR, LVDP and RPP at th