Relapse of neuroblastoma (NB) commonly occurs in hypoxic tissues. Buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthe-sis, is cytotoxic for NB cell lines in atmospheric oxygen (20 % O2). Tira-pazamine (TPZ) is a bioreductive agent that forms a toxic-free radical in hypoxia. We determined in four NB cell lines cytotoxicity using the DIMSCAN digital imaging fluorescence assay, glutathione (GSH) levels by the DTNB-GSSG reductase method, apoptosis, reactive oxygen species (ROS), and mitochondrial membrane potential (m) by flow cytometry. Hypoxia (2 % O2) antagonized BSO-mediated ROS, apoptosis, and cyto-toxicity but not GSH depletion. TPZ synergistically enhanced BSO cyto-toxicity in hypoxia for all four NB cell lines, achiev...
based regimens,>50 % of patients with high-risk neuroblastoma (NB) die from recurrent dis-ease th...
Neuroblastoma, a paediatric malignant tumor, is initially sensitive to etoposide, a drug to which ma...
Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To c...
Glutathione (GSH) depletion is widely used to sensitize cells to anticancer treatment inducing the p...
Glutathione (GSH) levels progressively decline during aging and in neurodegenerative disorders. Howe...
Hydroxyl radicals, superoxides, and hydrogen peroxides are common reactive oxygen species (ROS) that...
Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to c...
Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to c...
Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to c...
Cancer cell survival is known to be related to the ability to counteract oxidative stress, and gluta...
Glutathione (GSH) is implicated in drug resistance mechanisms of several cancers and is a key regula...
International audienceIn order to investigate the function of haem oxygenase in neuronal cell death ...
none7The total GSH depletion observed in the substantia nigra (SN) appears to be responsible for su...
Glutathione (GSH) is implicated in drug resistance mechanisms of several cancers and is a key regula...
Glutathione (GSH) depletion by buthioninine sulfoximine (BSO) is being explored clinically as a mean...
based regimens,>50 % of patients with high-risk neuroblastoma (NB) die from recurrent dis-ease th...
Neuroblastoma, a paediatric malignant tumor, is initially sensitive to etoposide, a drug to which ma...
Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To c...
Glutathione (GSH) depletion is widely used to sensitize cells to anticancer treatment inducing the p...
Glutathione (GSH) levels progressively decline during aging and in neurodegenerative disorders. Howe...
Hydroxyl radicals, superoxides, and hydrogen peroxides are common reactive oxygen species (ROS) that...
Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to c...
Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to c...
Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to c...
Cancer cell survival is known to be related to the ability to counteract oxidative stress, and gluta...
Glutathione (GSH) is implicated in drug resistance mechanisms of several cancers and is a key regula...
International audienceIn order to investigate the function of haem oxygenase in neuronal cell death ...
none7The total GSH depletion observed in the substantia nigra (SN) appears to be responsible for su...
Glutathione (GSH) is implicated in drug resistance mechanisms of several cancers and is a key regula...
Glutathione (GSH) depletion by buthioninine sulfoximine (BSO) is being explored clinically as a mean...
based regimens,>50 % of patients with high-risk neuroblastoma (NB) die from recurrent dis-ease th...
Neuroblastoma, a paediatric malignant tumor, is initially sensitive to etoposide, a drug to which ma...
Aerobic metabolism of mammalian cells leads to the generation of reactive oxygen species (ROS). To c...