CONVECTION-LIMITED SURFACE TRANSPORT IN NANOFLUIDIC CHANNELS

In this presentation, we describe the conditions under which transport and surface binding of analytes in microfluidic devices becomes convection-limited, i.e. limited by the influx of analyte to the detection zone. Convection-limitations appear in channels typically of less than 10 microns thick due to a high relative number of binding sites at the surface compared to the number of analytes in the bulk. The effect is experimentally observed and quantified in micron-size channels