Although extensive HLA-A and HLA-B polymorphism is evident, the true diversity of HLA-C has remained hidden due to poor resolution of HLA-C Ags. To better understand the polymorphic nature of HLA-C molecules, 1823 samples from the National Marrow Donor Program research repository in North America have been typed by DNA sequencing and interpreted in terms of HLA-C diversification. Results show that HLA-Cw*0701 was the most common allele with a frequency of 16%, whereas 28 % of the alleles typed as Cw12-18 (serologic blanks). The frequency of homozygotes was 9.8 % as compared with previous studies of 18% for sequence-specific primers and 50 % for serology. Most startling was the frequency at which new alleles were detected; 19 new HLA-C allel...
International audienceWith the aim to understand how next-generation sequencing (NGS) improves both ...
The gold standard for typing at the allele level of the highly polymorphic Human Leucocyte Antigen (...
<div><p>The 1000 Genomes Project aims to provide a deep characterization of human genome sequence va...
<div><p>HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage...
International audienceThe most polymorphic part of the human genome, the MHC, encodes over 160 prote...
The human leukocyte antigen (HLA) genes are extremely polymorphic and are useful molecular markers t...
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genom...
The genomic region of HLA gene cluster (6p21.3) contains several highly polymorphic genes involved i...
The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation ...
Matching for hla at the allele level is crucial for stem cell transplantation. The golden standard a...
Background – Histocompatibility locus antigen (HLA) class I typing by serology is the most common me...
Next generation sequencing (NGS) is currently being adapted by different biotechnological platforms ...
The markedly high levels of polymorphism present in classical class I loci of the human major histoc...
AbstractWe carried out a resequencing project that examined 552 kb of sequence from each of 46 indiv...
International audienceWith the aim to understand how next-generation sequencing (NGS) improves both ...
The gold standard for typing at the allele level of the highly polymorphic Human Leucocyte Antigen (...
<div><p>The 1000 Genomes Project aims to provide a deep characterization of human genome sequence va...
<div><p>HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage...
International audienceThe most polymorphic part of the human genome, the MHC, encodes over 160 prote...
The human leukocyte antigen (HLA) genes are extremely polymorphic and are useful molecular markers t...
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genom...
The genomic region of HLA gene cluster (6p21.3) contains several highly polymorphic genes involved i...
The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation ...
Matching for hla at the allele level is crucial for stem cell transplantation. The golden standard a...
Background – Histocompatibility locus antigen (HLA) class I typing by serology is the most common me...
Next generation sequencing (NGS) is currently being adapted by different biotechnological platforms ...
The markedly high levels of polymorphism present in classical class I loci of the human major histoc...
AbstractWe carried out a resequencing project that examined 552 kb of sequence from each of 46 indiv...
International audienceWith the aim to understand how next-generation sequencing (NGS) improves both ...
The gold standard for typing at the allele level of the highly polymorphic Human Leucocyte Antigen (...
<div><p>The 1000 Genomes Project aims to provide a deep characterization of human genome sequence va...