Herpes simplex virus viremia during primary genital infection

Primary genital herpes simplex virus (HSV) infection is com-monly associated with systemic symptoms. A systematic eval-uation of HSV viremia during primary genital infection has not been performed previously. Plasma samples from adults with a first clinical episode of genital HSV infection were as-sayed for HSV DNA by polymerase chain reaction. One hun-dred sixty-four adults had confirmed primary genital HSV in-fection. Of these, 40 (24%) had HSVDNA detected in plasma. Thirty-seven (93%) of 40 were infected with HSV-2. Viremic participants were more likely to be women, compared with aviremic participants (83 % vs. 61%; P .01). Viremia was de-tected more frequently and at a higher number of copies per milliliter early in infection. We conclude that HSV viremia during primary genital HSV infection is common, especially among women