Add to ORKGMismatch repair (MMR) is important for repairing of nucleotide mismatches during DNA replication. Germline mutations in MMR genes are associated with hereditary non-polyposis colorectal cancer (HNPCC). Ovarian can-cer occurs as part of the HNPCC phenotype, and so com-mon variants in MMR genes are candidates for ovarian cancer susceptibility. We performed a large multicentre case–control study to investigate associations of common variations in MMR genes and ovarian cancer using a single nucleotide polymorphism (SNP) tagging approach. A total of 2570 controls and 1531 cases from three separate studies were genotyped for 44 tagging SNPs (stSNP) in seven MMR genes (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2). Genotype frequencies were margina...
The value of identifying women with an inherited predisposition to epithelial ovarian cancer has bec...
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition...
BACKGROUND: The treatment of ovarian cancer is hindered by intrinsic or acquired resistance to plati...
Objective. Ovarian cancer has one of the highest fractions of hereditary cases. The hereditary breas...
BACKGROUND:Recent studies have identified several single nucleotide polymorphisms (SNPs) in the popu...
Ovarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are d...
The search for genetic variants associated with ovarian cancer risk has focused on pathways includin...
Low-moderate risk alleles that are relatively common in the population may explain a significant pro...
The search for genetic variants associated with ovarian cancer risk has focused on pathways includin...
A family history of ovarian or breast cancer is the strongest risk factor for epithelial ovarian can...
Abstract Background MMR is responsible for the repair of base-base mismatches and insertion/deletion...
Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of heredit...
Ovarian cancer is a highly lethal disease. Many researchers have, therefore, attempted to identify h...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
The value of identifying women with an inherited predisposition to epithelial ovarian cancer has bec...
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition...
BACKGROUND: The treatment of ovarian cancer is hindered by intrinsic or acquired resistance to plati...
Objective. Ovarian cancer has one of the highest fractions of hereditary cases. The hereditary breas...
BACKGROUND:Recent studies have identified several single nucleotide polymorphisms (SNPs) in the popu...
Ovarian cancer is a leading cause of gynecological cancer death and in Sweden nearly 700 cases are d...
The search for genetic variants associated with ovarian cancer risk has focused on pathways includin...
Low-moderate risk alleles that are relatively common in the population may explain a significant pro...
The search for genetic variants associated with ovarian cancer risk has focused on pathways includin...
A family history of ovarian or breast cancer is the strongest risk factor for epithelial ovarian can...
Abstract Background MMR is responsible for the repair of base-base mismatches and insertion/deletion...
Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of heredit...
Ovarian cancer is a highly lethal disease. Many researchers have, therefore, attempted to identify h...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian canc...
The value of identifying women with an inherited predisposition to epithelial ovarian cancer has bec...
Because both ovarian and breast cancer are hormone-related and are known to have some predisposition...
BACKGROUND: The treatment of ovarian cancer is hindered by intrinsic or acquired resistance to plati...