Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer

BACKGROUND. The use of androgen deprivation therapy (ADT) in the treatment of men with prostate cancer has risen sharply. Although cardiovascular disease is the most common reason for death among men with prostate cancer who do not die of the disease itself, data regarding the effect of ADT on cardiovascular mor-bidity and mortality in men with prostate cancer are limited. In the current study, the authors attempted to measure the risk for subsequent cardiovascular morbidity in men with prostate cancer who received ADT. METHODS. A cohort of newly diagnosed men in a population-based registry who were diagnosed between 1992 and 1996 were identified retrospectively. A total of 22,816 subjects were identified after exclusion criteria were applied. Using a mul-tivariate model, the authors calculated the risk of subsequent cardiovascular mor-bidity in men with prostate cancer who were treated with ADT, as defined using Medicare claims. RESULTS. Newly diagnosed prostate cancer patients who received ADT for at least 1 year were found to have a 20 % higher risk of serious cardiovascular morbidit