Original Contribution Association of DDT and DDE with Birth Weight and Length of Gestation in the Child Health and Development Studies, 1959–1967

The pesticide p,p#-dichlorodiphenyltrichloroethane (DDT) and its persistent metabolite p,p#-dichlorodiphenyldi-chloroethylene (DDE) are associated with negative reproductive outcomes in animals. In humans, however, the findings are inconsistent. Using data from the Child Health and Development Studies, a longitudinal study of 20,754 pregnancies among San Francisco Bay Area women from 1959 to 1967, the authors examined the effects of maternal serum DDT and DDE concentrations on preterm birth, small-for-gestational-age birth, birth weight, and gestational age in 420 male subjects. Data were analyzed using multivariate logistic regression for preterm and small-for-gestational-age birth and linear regression for birth weight and gestational age. Median serum concen