f3-N-Terminal Glycohemoglobins in Subjects with Common Hemoglobinopathies: Relation with Fructosamine and Mean ErythrocyteAge

rum fructosamine, and erythrocyte polyamines were de-termined in nondiabetic adults with HbAA, HbAC, HbAS, HbCC, HbSC, HbSS, and HbS/hereditary persistent HbF (HPFH). The groups did not differ in fructosamine con-centrations. Mean (95 % confidence limits) HbX1C percent-ages were: 4.4 (4.1-4.8) forHbAIC lfl HbAA, 4.3 (3.9-4.8) for HbAIC in HbAC, 4.1 (3.6-4.6) for HbC1C in HbAC, 4.4 (4.0-4.7) for HbA1 in HbAS, 2.6 (range: 2.3-3.8) for HbCic in HbCC, 2.0 (1.5-2.4) for HbS1C in HbSC, 0.9 (0.6-1.3) for HbS1C In HbSS, and 1.3 (range: 0.8-2.4) for HbSic in HbS/HPFH. There was a nonlinear inverse re-lation between HbXic and erythrocyte polyarnines, indi-cating that HbXIC percentage decreases with decreasing mean erythrocyte age. We conclude that amounts of HbXIC in subjects with heterozygous hemoglobinopathie