Shroom, a PDZ Domain±Containing Actin-Binding Protein, Is Required for Neural Tube Morphogenesis in Mice

as exencephaly, acrania, and craniofacial clefting, while caudal NTDs can result in spina bifida. A number of intrinsic and extrinsic genetic, molecular, and environmental factors that regulate neural tube mor-phogenesis in mice have been identified. For example