Add to ORKGThere are clones of myeloid leukemic cells that can be induced to undergo terminal cell differentiation to macrophages by normal hemopoietic regulatory proteins. Indudion of differentiation in two different clones of myeloid leukemic cells with interleukin 6 (IL-6) or granulocyte-macrophage colony-stimulating fador (GM-CSF) resulted in indudion of mRNA for the hemopoietic regulatory proteins IL-6, GM-CSF, interleukin ia and interleukin i, tumor necrosis fador, and transforming growth fador ft. In one of these clones, indudion of differentiation with GM-CSF was also associated with indudion of mRNA for macrophage colony-stimulating fador (M-CSF) but not for the receptor for M-CSF (c-fms), whereas in the other clone, indudion of differentiati...
Several activating mutations have recently been described in the common beta subunit for the human i...
We used the technique of representational difference analysis to identify genes expressed by the Jma...
In order to minimize the interactions of clonogenic cells with accessory cells and characterize the ...
To better understand the immediate early genetic response of myeboid cells to terminal differentiati...
Interleukin-6 (IL-6) and leukemia inhibitory factor (LIF), two multifunctional cytokines, recently h...
Factors involved in regulating tissue specific gene expression play a major role in cell differentia...
It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation in...
Abnormalities ln both growth and differentiation appear to be required for leukemogenesis. Hematopoi...
Hematopoiesis has been for many years seen as a straightforward process based on sequential restrict...
Mechanisms which regulate gene expression at the level of protein synthesis play an important role i...
Several activating mutations have recently been described in the common beta subunit for the human i...
Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic ce...
Studies in recent years have suggested that human tumor cell lines are capable of responding in vitr...
Abnormalities in both growth and differentiation appear to be required for leukemogenesis. Hematopoi...
The stringent requirement for hemopoietic growth factors (HGF) in the induction of hemopoiesis in vi...
Several activating mutations have recently been described in the common beta subunit for the human i...
We used the technique of representational difference analysis to identify genes expressed by the Jma...
In order to minimize the interactions of clonogenic cells with accessory cells and characterize the ...
To better understand the immediate early genetic response of myeboid cells to terminal differentiati...
Interleukin-6 (IL-6) and leukemia inhibitory factor (LIF), two multifunctional cytokines, recently h...
Factors involved in regulating tissue specific gene expression play a major role in cell differentia...
It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation in...
Abnormalities ln both growth and differentiation appear to be required for leukemogenesis. Hematopoi...
Hematopoiesis has been for many years seen as a straightforward process based on sequential restrict...
Mechanisms which regulate gene expression at the level of protein synthesis play an important role i...
Several activating mutations have recently been described in the common beta subunit for the human i...
Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic ce...
Studies in recent years have suggested that human tumor cell lines are capable of responding in vitr...
Abnormalities in both growth and differentiation appear to be required for leukemogenesis. Hematopoi...
The stringent requirement for hemopoietic growth factors (HGF) in the induction of hemopoiesis in vi...
Several activating mutations have recently been described in the common beta subunit for the human i...
We used the technique of representational difference analysis to identify genes expressed by the Jma...
In order to minimize the interactions of clonogenic cells with accessory cells and characterize the ...