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Non-Hodgkin lymphomas (NHL) accounts for 2.6 % of all cancer deaths in England and Wales and the incidence is increasing every year. Experimental data suggest that in NHL cells there are changes that would lead to an upregulation of anti-apoptotic proteins, down regulation of pro-apoptotic signals, and upregulation of proteins involved in cell adhesion. Chemicals that inhibit translational initiation include inhibitors of p38Mapkinase pathways (e.g. SB203580), ERK pathway (e.g. PD98059) and FRAP/mTOR pathway (e.g. Rapamycin and Wortmanin). We present a mathematical model of the signalling pathways associated with capped translation and use the model to predict whether it is possible to use translational inhibitors to chemosensitise NHL cells. We wish to determine whether it is possible to alter the expressio