Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhtsh or hormone withdrawal. J Nucl Med 2006;47:648–54

Technical aspects and results of the dosimetric assessments of postoperative radioiodine ablation in the framework of an inter-national, prospective, controlled, randomized, comparative study of the effectiveness of ablation therapy with 3.7 GBq 131I in differentiated thyroid cancer after stimulation with recombi-nant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are presented. Methods: Sixty-three patients were ran-domized after thyroidectomy to either the THW or the rhTSH group. Scintigraphic neck images were acquired starting 48 h af-ter radioiodine administration to assess biokinetics in the thyroi