Departments of 1Biochemistry,

treatment in diabetic rats, whereas were not occurred significantly an increase at 3 and 30 days in diabetic rats (p<0.05). Histopathologic examination of the kidneys showed that thickening of the glomerular basement membrane, glomerular sclerosis, tubular dilatation and “Capsular Cap ” oc-curred in the kidneys of STZ-induced-diabetic rats at 12 and 30 days. In summary, it can be considered that high serum, lung and kidney ACE activity levels were related to with the complications in di-abetic rats