Voxel based analysis of tissue volume MRI data

This document has been written to illustrate the role that assumptions play in the design of image analysis algorithms. We present several common methods for the segmentation of MR data on the basis of underlying tissue. These methods, which may appear disparate at first sight, are discussed and related in terms of the assumptions regarding the data fornmation process needed to derive them. We summarise the use of these techniques using a flow diagram which makes explicit the questions which need to be addressed in order that they are used appropriately