Genomic Organization and Localization of the Human CRMP-1

The Collapsin Response Mediator Protein-1 (CRMP-1) is a brain specific protein considered to be involved in the collapsin-induced growth cone collapse during neural development. CRMP-1 belongs to the Unc-33 gene family. Here we report the genomic structure and the localization of the human CRMP-1 gene to chromosome 4pl6.1. Sequence analysis revealed that the human CRMP-1 gene consists of 14 exons. We have also established sequencing assays for all its coding exons. This should permit the rapid screening for mutations to assess CRMP-1 role in genetic disorders mapped in the 4pl6.1 region. Key words: Human CRMP-1 gene; gene mapping; Exon-intron structure The cytoplasmic collapsin response mediator protein-1 (CRMP-1), also known as dihydropyrimidinase related protein-1 (DRP-1) is a brain specific protein that belongs to the Unc-33 related protein family.1'2-3 CRMP-1 pre-dicted amino acid identity is 84 % homologous to the chick crmp-62 gene, which is thought to be involved in the sig-naling cascade initiated by collapsin-1.1 Collapsin-1, i