Abstract. Analysis of the genome-wide patterns of single-nucleotide substitution reveals that the human GC content structure is out of equilibrium. The substitutions are decreasing the overall GC content (GC), at the same time making its range narrower. Investigation of single-nucleotide polymorphisms (SNPs) revealed that presently the decrease in GC content is due to a uniform mutational preference for A:T pairs, while its projected range is due to a variability in the fixation preference for G:C pairs. However, it is important to determine whether les-sons learned about evolutionary processes operating at the present time (that is reflected in the SNP data) can be extended back into the evolutionary past. We describe here a new approach t...
There are large-scale variations of the GC-content along mammalian chromosomes that have been called...
Abstract. This study presents the first global, 1-Mbp-level analysis of patterns of nucleotide subst...
Regional biases in substitution pattern are likely to be responsible for the large-scale variation i...
Abstract. Analysis of the genome-wide patterns of single-nucleotide substitution reveals that the hu...
Analysis of the genome-wide patterns of single-nucleotide substitution reveals that the human GC con...
We examined seventy million well-characterized human mutations, and their impact on G+C-compositiona...
GC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that accelerates...
Relative single base-pair substitution rates in human genes, derived from a collection of > 2,700 po...
GC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that accelerates...
Fast evolving regions of many metazoan genomes show a bias toward substitutions that change weak (A,...
Background Accurate knowledge of the core components of substitution rates is of vital importance to...
AbstractSo far, there is no genome-wide estimation of the mutational spectrum in humans. In this stu...
The rates and patterns at which nucleotide substitutions occur vary significantly across the genome ...
Abstract Background Accurate k...
Unraveling the evolutionary forces responsible for variations of neutral substitution patterns among...
There are large-scale variations of the GC-content along mammalian chromosomes that have been called...
Abstract. This study presents the first global, 1-Mbp-level analysis of patterns of nucleotide subst...
Regional biases in substitution pattern are likely to be responsible for the large-scale variation i...
Abstract. Analysis of the genome-wide patterns of single-nucleotide substitution reveals that the hu...
Analysis of the genome-wide patterns of single-nucleotide substitution reveals that the human GC con...
We examined seventy million well-characterized human mutations, and their impact on G+C-compositiona...
GC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that accelerates...
Relative single base-pair substitution rates in human genes, derived from a collection of > 2,700 po...
GC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that accelerates...
Fast evolving regions of many metazoan genomes show a bias toward substitutions that change weak (A,...
Background Accurate knowledge of the core components of substitution rates is of vital importance to...
AbstractSo far, there is no genome-wide estimation of the mutational spectrum in humans. In this stu...
The rates and patterns at which nucleotide substitutions occur vary significantly across the genome ...
Abstract Background Accurate k...
Unraveling the evolutionary forces responsible for variations of neutral substitution patterns among...
There are large-scale variations of the GC-content along mammalian chromosomes that have been called...
Abstract. This study presents the first global, 1-Mbp-level analysis of patterns of nucleotide subst...
Regional biases in substitution pattern are likely to be responsible for the large-scale variation i...