Scintigraphic detection of occult disease is limited by background activity in the blood and in the extravascular space that reduces target-specific contrast. To lower nonspecific background activity, we have studied the in vivo biodistribution kinetics of a clot-targeting molecule (MH1 Fab') attached to 99mTc-dextran.We tested the hypothesis that the complex will have better back ground clearance than the directly radiolabeled clot-targeting molecule. Methods: Fab ' fragments of MH1 Fab ' antifibrin antibody were coupled to "Tc-sulfhydryl dextran through disul-fide exchange, and clot binding bioreactivity was tested in vitro and in vivo in a rabbit jugular vein thrombus model. To assess the background clearance kinetics...
Balb/c mice were immunized with human plasmin-generated fibrinogen degradation product Y. Spleen cel...
Background. The T2Gls monoclonal antifibrin antibody binds specifically to fibrin but not to fibrino...
The efficacy of thrombolysis is inversely correlated with thrombus age. During early thrombogenesis,...
Aim: The aim of this study was to investigate the possibility of using 99mtechnetium (99mTc)-labeled...
Introduction: Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus...
Imaging of acute thrombus, especially the very prevalent condition of acute deep vein thrombosis is ...
Deep vein thrombosis (DVT) and pulmonary embolism (PE) are different aspects of a single condition, ...
99mTc-Sulesomab, the Fab fragment of anti–NCA-90, is used as an in vivo granulocyte labeling agent f...
A pentapeptide, Gly-Pro-Arg-Pro-Pro, with high affinity for a-chain-fibrin was labeled with 99mTc (9...
Monoclonal antibody 59D8 developed by Hui et al., binds to fibrin but not fibrinogen. An 111ln label...
IntroductionThrombi in contact with non re-endothelialized stent struts associated with drug-eluting...
Purpose 99mTc-DI-DD3B6/22-80B3 (ThromboView®, hereafter abbreviated to 99mTc-DI-80B3 Fab′) is a radi...
The development of radiolabeled small peptide or peptidomimetic ligands can bind platelets and their...
Imaging of acute thrombus, especially the very prevalent condition of acute deep vein thrombosis is ...
Marija Darkovska-Serafimovska,1,2 Emilija Janevik-Ivanovska,1 Icko Djorgoski,2 Zorica Arsova-Sarafin...
Balb/c mice were immunized with human plasmin-generated fibrinogen degradation product Y. Spleen cel...
Background. The T2Gls monoclonal antifibrin antibody binds specifically to fibrin but not to fibrino...
The efficacy of thrombolysis is inversely correlated with thrombus age. During early thrombogenesis,...
Aim: The aim of this study was to investigate the possibility of using 99mtechnetium (99mTc)-labeled...
Introduction: Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus...
Imaging of acute thrombus, especially the very prevalent condition of acute deep vein thrombosis is ...
Deep vein thrombosis (DVT) and pulmonary embolism (PE) are different aspects of a single condition, ...
99mTc-Sulesomab, the Fab fragment of anti–NCA-90, is used as an in vivo granulocyte labeling agent f...
A pentapeptide, Gly-Pro-Arg-Pro-Pro, with high affinity for a-chain-fibrin was labeled with 99mTc (9...
Monoclonal antibody 59D8 developed by Hui et al., binds to fibrin but not fibrinogen. An 111ln label...
IntroductionThrombi in contact with non re-endothelialized stent struts associated with drug-eluting...
Purpose 99mTc-DI-DD3B6/22-80B3 (ThromboView®, hereafter abbreviated to 99mTc-DI-80B3 Fab′) is a radi...
The development of radiolabeled small peptide or peptidomimetic ligands can bind platelets and their...
Imaging of acute thrombus, especially the very prevalent condition of acute deep vein thrombosis is ...
Marija Darkovska-Serafimovska,1,2 Emilija Janevik-Ivanovska,1 Icko Djorgoski,2 Zorica Arsova-Sarafin...
Balb/c mice were immunized with human plasmin-generated fibrinogen degradation product Y. Spleen cel...
Background. The T2Gls monoclonal antifibrin antibody binds specifically to fibrin but not to fibrino...
The efficacy of thrombolysis is inversely correlated with thrombus age. During early thrombogenesis,...