Mapping blood pressure loci in (A/J x B6)F2 mice

2003; 10.1152/physiolgenomics.00027.2003.—Although the ge-netics of rare, monogenic, forms of human hypertension are fairly well defined, the genetics of the common polygenic form of human essential hypertension is only emerging. With the ability to control environmental variables, animal models have provided valuable tools with which to study blood pres-sure (BP) homeostasis. We have now studied BP genetics in a model consisting of 1,521 F2 mice from a series of (A/J B6) intercrosses kept under standardized conditions. Using whole genome quantitative trait loci (QTL) mapping, we have identified four novel significant BP loci. These included Abbp1 on mouse chromosome MMU1 [maximum LOD score (MLS) at35 cM 6.8], Abbp2 on MMU4 (MLS at25 cM 9.8), Abbp3 on MMU7 (MLS at 25 cM 5.4), and Abbp4 on MMU11 (MLS at58 cM 6.3). Compared with A/J homozy