250 American Society of Hematology Engineering Antitumor Immunity by T-Cell Adoptive Immunotherapy

The adoptive transfer of antigen-specific T cells has been used successfully to treat experimental tumors in animal models and viral infections in humans, but harnessing the exquisite specificity and potency of T cells to treat human malignancy has proven challeng-ing. The efforts to use T cells to treat patients with cancer have often been informative in identifying limitations that must be overcome to improve thera-peutic efficacy, and a clearer picture of the require-ments for successful adoptive T-cell transfer is gradually emerging. Indolent and a subset of aggres-sive B-cell lymphomas in humans have been shown to be susceptible to eradication by T cells in clinical settings where highly immunogenic minor histocom-patibility or viral antigens are presented by tumo