Enhancement of antiviral activity against by interferon combination

Alpha, beta, and gamma interferons (IFN-, IFN-, IFN-) have been shown to be effective inhibitors of HCV replication in human cell lines carrying HCV replicons. To help define the divergent cellular processes involved in the control of intracellular HCV replication by these agents, we have characterized the activity of monotherapies and combination therapies with the major types of human interferons against HCV replication in the HCV replicon-containing cell line, AVA5. IFN-, IFN-, and omega interferon (IFN-) were equally effective at inhibiting HCV replication, while IFN- was approximately 10-fold more potent. In kinetic experiments, IFN- and IFN- inhibited HCV replication more rapidly enhanced an additive to s IFN-/IFN-in the combi in cell cultur human cytok in HCV repl more effecti the anti-HC