Genetic Analysis of the CYP2D6 Locus in a Hong Kong Chinese Population

debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as tricyclic anti-depressants and neuroleptics. Genetic polymorphism of the CYP2D6 gene is responsible for pronounced inter-individual and interracial differences in the metabolism of these drugs. The CYP2D6*10 allele and its variants are the most frequent alleles found in Orientals, and they are responsible for diminished debrisoquine 4-hydrox-ylase activity because of the presence of a C1883T mutation in exon 1. Methods: One hundred nineteen Hong Kong Chinese subjects were genotyped by means of allele-specific PCR, PCR, and restriction enzyme analysis for 1