Association of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutation/Variant/Haplotype and Tumor Necrosis Factor (TNF) Promoter

eridemia (HTG) leads to pancreatitis is not clear. We sought to determine whether the genes involved in pan-creatic ductal or acinar cell injury, including the cationic trypsinogengene[protease, serine,1 (trypsin1) (PRSS1)], the pancreatic secretory trypsin inhibitor gene [serine peptidase inhibitor, Kazal type 1 (SPINK1)], the cystic fi-brosis transmembrane conductance regulator gene [cys-tic fibrosis transmembrane conductance regulator (ATP-binding cassette subfamily C, member 7) (CFTR)], and inflammationgenes such as tumornecrosis factor [tumor necrosis factor, TNF superfamily, member 2 (TNF)] are associated with hyperlipidemic pancreatitis (HLP) in pa-tients with HTG. METHODS: We performed genetic analysis of 126 HTG patients in Taiwan (46 withHLP and 80 without HLP). The entire coding and intronic regions of the PRSS1, SPINK1, and CFTR genes were identified by heterodu-plex analysis techniques and were confirmed by se-quencing analysis. The presence of 125G/C, 1001 11CT, 1540AG (Met470Val), 2694TG, and 4521GA in CFTR, the presence of 272CT i