Rho Signaling: Where is the Feedback?

The GTPase Rho forms part of a G-protein signaling system and is known to stimulate changes to the actin cytoskeleton important for cell motility responses such as cell migration, neurite outgrowth and phagocytosis. Targeting Rho signaling has been suggested as a potential route to treat a number of diseases, including cancer and heart disease [2, 4]. Several recent reviews of the Rho signaling pathway have depicted it as a feedforward cascade of interactions [1, 3], as depicted in th