Large-scale genomic sequencing requires a software infrastructure to support and integrate applications that are not directly compatible. We describe a suite of software tools built around the Common Assembly Format (CAF), a comprehensive representation of a sequence assembly as a text file. These tools form the backbone of sequencing informatics at the Sanger Centre and the Genome Sequencing Center. The CAF format is intentionally flexible, and our Perl and C libraries, which parse and manipulate it, provide powerful tools for creating new applications as well as wrappers to incorporate other software. The tools are available free by anonymous FTP fro
Summary: Scientists now use high-throughput sequencing technologies and short-read assembly methods ...
Despite the prodigious throughput of the sequencing instruments currently on the market, the assembl...
The development of “next-generation” high-throughput sequencing technologies has made it possible fo...
Despite the rapidly increasing number of sequenced and re-sequenced genomes, many issues regarding t...
DNA sequencing and assembly is the Philosopher's Stone of bioinformatics, where the raw material of ...
Several sequencing technologies have been introduced in recent years that dramatically outperform th...
Low-cost DNA sequencing technologies have expanded the role for direct nucleic acid sequencing in th...
Motivation: Genome-scale DNA sequencing is a multistep process in which large numbers of small templ...
The advent of next-generation sequencing technologies is accompanied with the development of many wh...
Whole genome sequencing has become a powerful tool in modern microbiology. Especially bacterial geno...
The process of sequencing a genome involves many steps, and accordingly, this project contains wor...
From the date its role in heredity was discovered, DNA has been generating interest among scientists...
Next generation sequence technologies (NGS) made possible to sequence entirely genomes in a fast way...
Genome assembly in its two decades of history has produced significant research, in terms of both bi...
SUMMARY: Due to the availability of new sequencing technologies, we are now increasingly interested ...
Summary: Scientists now use high-throughput sequencing technologies and short-read assembly methods ...
Despite the prodigious throughput of the sequencing instruments currently on the market, the assembl...
The development of “next-generation” high-throughput sequencing technologies has made it possible fo...
Despite the rapidly increasing number of sequenced and re-sequenced genomes, many issues regarding t...
DNA sequencing and assembly is the Philosopher's Stone of bioinformatics, where the raw material of ...
Several sequencing technologies have been introduced in recent years that dramatically outperform th...
Low-cost DNA sequencing technologies have expanded the role for direct nucleic acid sequencing in th...
Motivation: Genome-scale DNA sequencing is a multistep process in which large numbers of small templ...
The advent of next-generation sequencing technologies is accompanied with the development of many wh...
Whole genome sequencing has become a powerful tool in modern microbiology. Especially bacterial geno...
The process of sequencing a genome involves many steps, and accordingly, this project contains wor...
From the date its role in heredity was discovered, DNA has been generating interest among scientists...
Next generation sequence technologies (NGS) made possible to sequence entirely genomes in a fast way...
Genome assembly in its two decades of history has produced significant research, in terms of both bi...
SUMMARY: Due to the availability of new sequencing technologies, we are now increasingly interested ...
Summary: Scientists now use high-throughput sequencing technologies and short-read assembly methods ...
Despite the prodigious throughput of the sequencing instruments currently on the market, the assembl...
The development of “next-generation” high-throughput sequencing technologies has made it possible fo...