ly to this article.

Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are un-known. Methods We performed a 2-year, placebo-controlled, randomized, double-blind study involving 87 elderly men with low levels of the sulfated form of DHEA and bioavailable testos-terone and 57 elderly women with low levels of sulfated DHEA. Among the men, 29 received DHEA, 27 received testosterone, and 31 received placebo. Among the wom-en, 27 received DHEA and 30 received placebo. Outcome measures included physical performance, body composition, bone mineral density (BMD), glucose tolerance, and quality of life. Results As compared with the change from baseline to 24 months in the placebo group, sub-jects who received DHEA for 2 years had an increase in plasma levels of sulfated DHEA by a median of 3.4 μg per milliliter (9.2 μmol per liter) in men and by 3.8 μg per mil