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Mutations in XPA That Prevent Association with ERCC1 Are Defective in Nucleotide Excision Repair

Mol Cell Biol
L Li
C A Peterson
X Lu
R J Legerski
Lei Li
Carolyn A. Peterson
Xiaoyan Lu
Randy
J. Legerski

Publication date

January 1995

DOI

10.1128/mcb.15.4.1993

ISSN

0270-7306

Abstract

repair. ERCC1 are defective in nucleotide excision Mutations in XPA that prevent association wit

Extracted data

Related items

The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I.

Duin, Mark
Vredeveldt, G.
Mayne, L.V.
Odijk, Hanny
Vermeulen, Wim
Weeda, Geert
Klein, Binie
Hoeijmakers, Jan
Bootsma, Dirk
Westerveld, Andries

January 1989

The human DNA excision repair gene ERCC-1 complements the ultraviolet light (UV) and mitomycin C (MM...

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Ahmad, Anwaar
Enzlin, Jacqueline H
Bhagwat, Nikhil R
Wijgers, Nils
Raams, Anja
Appledoorn, Esther
Theil, Arjan F
J Hoeijmakers, Jan H
Vermeulen, Wim
J Jaspers, Nicolaas G
Schärer, Orlando D
Niedernhofer, Laura J

March 2010

Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER...

The knock-down of ERCC1 but not of XPF causes multinucleation.

Rageul, Julie
Frëmin, Christophe
Ezan, Frédéric
Baffet, Georges
Langouët, Sophie

September 2011

International audienceExcision repair cross complementing gene 1 (ERCC1) associated with xeroderma p...

The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways

Orelli, Barbara
McClendon, T. Brooke
Tsodikov, Oleg V.
Ellenberger, Tom
Niedernhofer, Laura J.
Schaerer, Orlando D.

February 2010

The endonuclease ERCC1-XPF incises the damaged strand of DNA 5' to a lesion during nucleotide e...

Mutational analysis of the human nucleotide excision repair gene ERCC1. Nucleic Acids Res

Anneke M. Sijbers
Peter J. Van Der Spek
Hanny Odijk
Joke Van Den Berg
Marcel Van Duin
Andries Westerveld
Nicolaas G. J. Jaspers
Dirk Bootsma

January 1996

The human DNA repair protein ERCC1 resides in a complex together with the ERCC4, ERCC11 and XP-F cor...

Mutational analysis of the human nucleotide excision repair gene ERCC1.

Sijbers, A.M. (Anneke)
Spek, P.J. (Peter) van der
Odijk, H. (Hanny)
Berg, J.H. (Jan) van den
Duin, M. (Mark) van
Westerveld, A. (Andries)
Jaspers, N.G.J. (Nicolaas)
Bootsma, D. (Dirk)
Hoeijmakers, J.H.J. (Jan)

January 1996

The human DNA repair protein ERCC1 resides in a complex together with the ERCC4, ERCC11 and XP-F cor...

Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein

Nagai, A.
Saijo, Masafumi
Kuraoka, I.
Matsuda, Toshiro
Kodo, Naohiko
Nakatsu, Yoshimichi
Mimaki, T.
Mino, M.
Biggerstaff, Maureen
Wood, Richard
Sijbers, Anneke
Hoeijmakers, Jan
Tanaka, Kiyoji

June 1995

textabstractThe human XPA and ERCC1 proteins, which are involved in early steps of nucleotide excisi...

Evidence for a repair enzyme complex involving ERCC1, and the correcting activities of ERCC4, ERCC11 and the xeroderma pigmentosum group F.

Vuuren, Hanneke
Appeldoorn, Esther
Odijk, Hanny
Yasui, Akira
Jaspers, Nicolaas
Bootsma, Dirk
Hoeijmakers, Jan

January 1993

Nucleotide excision repair (NER), one of the major cellular DNA repair systems, removes a wide range...

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

Tsodikov, Oleg V.
Ivanov, Dmitri
Orelli, Barbara
Staresincic, Lidija
Shoshani, Ilana
Oberman, Robert
Scharer, Orlando D.
Wagner, Gerhard
Ellenberger, Tom

November 2007

The nucleotide excision repair (NER) pathway corrects DNA damage caused by sunlight, environmental m...

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions

Schrader, C.E.
Vardo, J.
Linehan, E.
Twarog, M.Z.
Niedernhofer, Laura
Stavnezer, J.
Hoeijmakers, Jan

January 2004

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision D...

Nucleotide excision repair syndromes: molecular basis and clinical symptoms.

Bootsma, Dirk
Weeda, Geert
Vermeulen, Wim
Vuuren, H.
Troelstra, Christine
Hoeijmakers, Jan
Spek, Peter

January 1995

The phenotypic consequences of a nucleotide excision repair (NER) defect in man are apparent from th...

ERCC1-XPF endonuclease facilitates DNA double-strand break repair

Ahmad, Riris
Robinson, Andria Rasile
Duensing, Anette
Drunen, Ellen
Beverloo, Berna
Weisberg, David
Hasty, Paul
Hoeijmakers, Jan
Niedernhofer, Laura

August 2008

textabstractERCC1-XPF endonuclease is required for nucleotide excision repair (NER) of helix-distort...

Mapping of the interaction domains between human repair proteins ERCC1 and XPF.

Laat, Wouter
Sijbers, Anneke
Odijk, Hanny
Appeldoorn, Esther
Jaspers, Nicolaas
Hoeijmakers, Jan

September 1998

ERCC1-XPF is a heterodimeric protein complexinvolved in nucleotide excision repair and recombination...

Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC.

Bernardes de Jesus, Bruno, M.
Bjørås, Magnar
Coin, Frédéric
Egly, Jean Marc

December 2008

International audienceXPC is responsible for DNA damage sensing in nucleotide excision repair (NER)....

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

Apelt, K
White, SM
Kim, HS
Yeo, J-E
Kragten, A
Wondergem, AP
Rooimans, MA
Gonzalez-Prieto, R
Wiegant, WW
Lunke, S
Flanagan, D
Pantaleo, S
Quinlan, C
Hardikar, W
van Attikum, H
Vertegaal, ACO
Wilson, BT
Wolthuis, RMF
Scharer, OD
Luijsterburg, MS

March 2021

ERCC1-XPF is a multifunctional endonuclease involved in nucleotide excision repair (NER), interstran...

The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I.

Duin, Mark
Vredeveldt, G.
Mayne, L.V.
Odijk, Hanny
Vermeulen, Wim
Weeda, Geert
Klein, Binie
Hoeijmakers, Jan
Bootsma, Dirk
Westerveld, Andries

January 1989

The human DNA excision repair gene ERCC-1 complements the ultraviolet light (UV) and mitomycin C (MM...

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Ahmad, Anwaar
Enzlin, Jacqueline H
Bhagwat, Nikhil R
Wijgers, Nils
Raams, Anja
Appledoorn, Esther
Theil, Arjan F
J Hoeijmakers, Jan H
Vermeulen, Wim
J Jaspers, Nicolaas G
Schärer, Orlando D
Niedernhofer, Laura J

March 2010

Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER...

The knock-down of ERCC1 but not of XPF causes multinucleation.

Rageul, Julie
Frëmin, Christophe
Ezan, Frédéric
Baffet, Georges
Langouët, Sophie

September 2011

International audienceExcision repair cross complementing gene 1 (ERCC1) associated with xeroderma p...

The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways

Orelli, Barbara
McClendon, T. Brooke
Tsodikov, Oleg V.
Ellenberger, Tom
Niedernhofer, Laura J.
Schaerer, Orlando D.

February 2010

The endonuclease ERCC1-XPF incises the damaged strand of DNA 5' to a lesion during nucleotide e...

Mutational analysis of the human nucleotide excision repair gene ERCC1. Nucleic Acids Res

Anneke M. Sijbers
Peter J. Van Der Spek
Hanny Odijk
Joke Van Den Berg
Marcel Van Duin
Andries Westerveld
Nicolaas G. J. Jaspers
Dirk Bootsma

January 1996

The human DNA repair protein ERCC1 resides in a complex together with the ERCC4, ERCC11 and XP-F cor...

Mutational analysis of the human nucleotide excision repair gene ERCC1.

Sijbers, A.M. (Anneke)
Spek, P.J. (Peter) van der
Odijk, H. (Hanny)
Berg, J.H. (Jan) van den
Duin, M. (Mark) van
Westerveld, A. (Andries)
Jaspers, N.G.J. (Nicolaas)
Bootsma, D. (Dirk)
Hoeijmakers, J.H.J. (Jan)

January 1996

The human DNA repair protein ERCC1 resides in a complex together with the ERCC4, ERCC11 and XP-F cor...

Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein

Nagai, A.
Saijo, Masafumi
Kuraoka, I.
Matsuda, Toshiro
Kodo, Naohiko
Nakatsu, Yoshimichi
Mimaki, T.
Mino, M.
Biggerstaff, Maureen
Wood, Richard
Sijbers, Anneke
Hoeijmakers, Jan
Tanaka, Kiyoji

June 1995

textabstractThe human XPA and ERCC1 proteins, which are involved in early steps of nucleotide excisi...

Evidence for a repair enzyme complex involving ERCC1, and the correcting activities of ERCC4, ERCC11 and the xeroderma pigmentosum group F.

Vuuren, Hanneke
Appeldoorn, Esther
Odijk, Hanny
Yasui, Akira
Jaspers, Nicolaas
Bootsma, Dirk
Hoeijmakers, Jan

January 1993

Nucleotide excision repair (NER), one of the major cellular DNA repair systems, removes a wide range...

Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

Tsodikov, Oleg V.
Ivanov, Dmitri
Orelli, Barbara
Staresincic, Lidija
Shoshani, Ilana
Oberman, Robert
Scharer, Orlando D.
Wagner, Gerhard
Ellenberger, Tom

November 2007

The nucleotide excision repair (NER) pathway corrects DNA damage caused by sunlight, environmental m...

Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions

Schrader, C.E.
Vardo, J.
Linehan, E.
Twarog, M.Z.
Niedernhofer, Laura
Stavnezer, J.
Hoeijmakers, Jan

January 2004

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision D...

Nucleotide excision repair syndromes: molecular basis and clinical symptoms.

Bootsma, Dirk
Weeda, Geert
Vermeulen, Wim
Vuuren, H.
Troelstra, Christine
Hoeijmakers, Jan
Spek, Peter

January 1995

The phenotypic consequences of a nucleotide excision repair (NER) defect in man are apparent from th...

ERCC1-XPF endonuclease facilitates DNA double-strand break repair

Ahmad, Riris
Robinson, Andria Rasile
Duensing, Anette
Drunen, Ellen
Beverloo, Berna
Weisberg, David
Hasty, Paul
Hoeijmakers, Jan
Niedernhofer, Laura

August 2008

textabstractERCC1-XPF endonuclease is required for nucleotide excision repair (NER) of helix-distort...

Mapping of the interaction domains between human repair proteins ERCC1 and XPF.

Laat, Wouter
Sijbers, Anneke
Odijk, Hanny
Appeldoorn, Esther
Jaspers, Nicolaas
Hoeijmakers, Jan

September 1998

ERCC1-XPF is a heterodimeric protein complexinvolved in nucleotide excision repair and recombination...

Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC.

Bernardes de Jesus, Bruno, M.
Bjørås, Magnar
Coin, Frédéric
Egly, Jean Marc

December 2008

International audienceXPC is responsible for DNA damage sensing in nucleotide excision repair (NER)....

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients

Apelt, K
White, SM
Kim, HS
Yeo, J-E
Kragten, A
Wondergem, AP
Rooimans, MA
Gonzalez-Prieto, R
Wiegant, WW
Lunke, S
Flanagan, D
Pantaleo, S
Quinlan, C
Hardikar, W
van Attikum, H
Vertegaal, ACO
Wilson, BT
Wolthuis, RMF
Scharer, OD
Luijsterburg, MS

March 2021

ERCC1-XPF is a multifunctional endonuclease involved in nucleotide excision repair (NER), interstran...

The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I.

Duin, Mark
Vredeveldt, G.
Mayne, L.V.
Odijk, Hanny
Vermeulen, Wim
Weeda, Geert
Klein, Binie
Hoeijmakers, Jan
Bootsma, Dirk
Westerveld, Andries

January 1989

The human DNA excision repair gene ERCC-1 complements the ultraviolet light (UV) and mitomycin C (MM...

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Ahmad, Anwaar
Enzlin, Jacqueline H
Bhagwat, Nikhil R
Wijgers, Nils
Raams, Anja
Appledoorn, Esther
Theil, Arjan F
J Hoeijmakers, Jan H
Vermeulen, Wim
J Jaspers, Nicolaas G
Schärer, Orlando D
Niedernhofer, Laura J

March 2010

Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER...

The knock-down of ERCC1 but not of XPF causes multinucleation.

Rageul, Julie
Frëmin, Christophe
Ezan, Frédéric
Baffet, Georges
Langouët, Sophie

September 2011

International audienceExcision repair cross complementing gene 1 (ERCC1) associated with xeroderma p...