COMPARISON BETWEEN BICARBONATE/LACTATE AND STANDARD LACTATE DIALYSIS SOLUTION IN PERITONEAL TRANSPORT AND ULTRAFILTRATION: A PROSPECTIVE, CROSSOVER SINGLE-DWELL STUDY

¤ Objective: It has been proposed that biocompatible bicarbonate/lactate based (Bic/Lac), physiologic-pH peri-toneal dialysis (PD) solutions will be beneficial in long-term PD. However, we do not yet have detailed knowledge con-cerning the comparative physiology of buffer transport for these new solutions and their impact on underlying perito-neal transport of solutes and ultrafiltration (UF). The pur-pose of this study was to investigate the profile of buffer handling and peritoneal membrane transport characteris-tics during a single dwell of the new Bic/Lac-based versus standard lactate-based (Lac) PD solution. ¤ Methods: In this prospective crossover study, we com-pared a 25 mmol/L bicarbonate/15 mmol/L lactate buff-ered, physiologic pH, low glucose degradation product (GDP) solution (Physioneal; Baxter Healthcare, McGaw Park