The morphogen Sonic hedgehog (Shh) is expressed by the projection neurons of the retina, retinal ganglion cells (RGCs), and promotes retinal precursor cell (RPC) proliferation. To distinguish between direct and indirect effects of Hedgehog (Hh) pathway activation in the perinatal mouse retina, we followed the fate of cells that expressed a constitutively active allele of Smoothened (SMO-M2), the signal transduction component of the Hh pathway. SMO-M2 expression promoted a cell-autonomous increase in CyclinD1 expression and RPC proliferation and biased RPC towards the production of cells with an inner nuclear layer fate at the expense of rod photoreceptors. SMO-M2 expression also inhibited rhodopsin expression in uninfected cells, thus highl...
Deciphering how signaling pathways interact during development is necessary for understanding the et...
The Hedgehog (Hh) signaling pathway in vertebrates is regulated by the interaction of three key comp...
Deregulation of the Hedgehog (Hh) signaling pathway is associated with the development of human canc...
The adult mouse retina is a laminated assemblage of specialized neurons and glia, which serves as a ...
AbstractThe development of extraocular orbital structures, in particular the choroid and sclera, is ...
AbstractThe development of extraocular orbital structures, in particular the choroid and sclera, is ...
International audienceMutations in effectors of the Hedgehog signaling pathway are responsible for a...
International audienceMutations in effectors of the Hedgehog signaling pathway are responsible for a...
These authors contributed equally to this work. Sonic Hedgehog (Shh) signaling is an important deter...
Sonic Hedgehog (Shh) signaling is an important determinant of vertebrate retinal ganglion cell (RGC)...
During embryonic development, the Hedgehog (Hh) signaling pathway plays an important role in the gro...
AbstractHedgehog (Hh) signaling is required for eye development in vertebrates; known roles in the z...
Journal ArticleThe hedgehog gene family encodes secreted proteins important in many developmental pa...
AbstractVertebrate retinal progenitor cells (RPCs) undergo a robust proliferative expansion to produ...
Various studies suggest that Hedgehog (Hh) signalling plays roles in human and zebrafish ocular deve...
Deciphering how signaling pathways interact during development is necessary for understanding the et...
The Hedgehog (Hh) signaling pathway in vertebrates is regulated by the interaction of three key comp...
Deregulation of the Hedgehog (Hh) signaling pathway is associated with the development of human canc...
The adult mouse retina is a laminated assemblage of specialized neurons and glia, which serves as a ...
AbstractThe development of extraocular orbital structures, in particular the choroid and sclera, is ...
AbstractThe development of extraocular orbital structures, in particular the choroid and sclera, is ...
International audienceMutations in effectors of the Hedgehog signaling pathway are responsible for a...
International audienceMutations in effectors of the Hedgehog signaling pathway are responsible for a...
These authors contributed equally to this work. Sonic Hedgehog (Shh) signaling is an important deter...
Sonic Hedgehog (Shh) signaling is an important determinant of vertebrate retinal ganglion cell (RGC)...
During embryonic development, the Hedgehog (Hh) signaling pathway plays an important role in the gro...
AbstractHedgehog (Hh) signaling is required for eye development in vertebrates; known roles in the z...
Journal ArticleThe hedgehog gene family encodes secreted proteins important in many developmental pa...
AbstractVertebrate retinal progenitor cells (RPCs) undergo a robust proliferative expansion to produ...
Various studies suggest that Hedgehog (Hh) signalling plays roles in human and zebrafish ocular deve...
Deciphering how signaling pathways interact during development is necessary for understanding the et...
The Hedgehog (Hh) signaling pathway in vertebrates is regulated by the interaction of three key comp...
Deregulation of the Hedgehog (Hh) signaling pathway is associated with the development of human canc...