ARTICLE NO FA972373 Two-Generation Reproductive Toxicity Study of Dietary Tributyl Phosphate in CD Rats1

Tributyl phosphate (TBP) was tested for reproductive toxicity in rats. Thirty weanlings/sex (F0) were exposed to TBP in the diet ad libitum at 0, 200, 700, or 3000 ppm for 10 weeks and then randomly mated within groups for 3 weeks with continued exposure. F0 parents and 10 Fl weanlings/sex/dose were necrop-sied, and adult reproductive organs, urinary bladders (both sexes), kidneys (males), and livers (females) were evaluated histo-logically. Thirty Fl weanlings/sex/dose continued exposure for 11 weeks and were bred as described above. Fl parents and F2 weanlings, 10/sex/dose, were then necropsied as described above. Adult toxicity was observed in both sexes and generations at 700 and 3000 ppm; observations included reduced body weights, weight gain and feed consumption, urinary bladder epithelial hyperplasia (both sexes), renal pelvis epithelial hyperplasia only at 3000 ppm (male kidneys), and centrilobular hypertrophy (fe